"CITRATE-FREE INJECTION TRAINING VIDEO PEDS SYRINGE" TRANSCRIPT

[Text on Screen and Spoken] This demonstration video offers you help and guidance for injecting with the HUMIRA® prefilled syringe. Watch it and read the entire Patient Instructions for Use found in your HUMIRA package. Don’t try to inject HUMIRA yourself until your doctor has decided you can, and you’ve been shown the right way to give injections.

Throughout this video, you will hear from actual patients. Individual experiences may vary.

[Text on Screen] Please see Uses and Important Safety Information within the website. Please see accompanying full Prescribing Information, including Patient Instructions for Use and Medication Guide, and discuss with your child’s doctor.

[SUPER] HUMIRA Complete mnemonic

[Text on Screen] INJECTING HUMIRA WITH RESOURCES DESIGNED AROUND YOU

TOM:

Welcome and thanks for joining us. I’m Tom, also known as Dad, and this is my daughter, Jessica.

JESSICA:

Hi.

TOM:

And we’re here to talk about how to take HUMIRA. I know, injecting your child probably isn’t anyone’s favorite subject, but it’s an important one. I get it. So, together with Jessica here, we’re going to help you learn how to properly inject. Before we start, I want you to know that there are a lot more ways HUMIRA Complete can help you out than this video. Because there’s more to making HUMIRA a routine part of your lives than making sure you’re giving your child their medication correctly. So, if you’re concerned about being able to afford your child’s medication, or have questions about insurance, or are wondering how you can do this on your own, HUMIRA Complete can help you get the answers you need, when you need them. You even have a dedicated Nurse Ambassador available to you.

[SUPER] [HUMIRA Complete logo]

[Text on Screen] Call 1.800.4HUMIRA

[Text on Screen] Request a HUMIRA Complete Nurse Ambassador* at 1.800.4HUMIRA

*Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

So, whether you are just starting or have been taking it for a while, HUMIRA Complete is here for you. Everyone has a different perspective about injecting, and throughout this video, you’ll hear some of them.

VICTORIA:

I like dancing, I like science class.

JACOB:

I really like sports. I’ve been in them almost all my life.

CHLOE:

The first time I was injected, it was really hard. I was so scared. I felt like they were almost more nervous than me, and I guess it helps that I wasn’t administering the shot yet.

HEIDI:

Right from the start, he felt like he wanted to own it himself.

MARK:

It’s hard to have to do it, and I mean, she’s just so strong.

VICTORIA:

Oh don’t you start crying! Mom...

TOM:

Obviously, it isn’t the easiest thing for your kid—or for you. So, after giving your child their medication, you might want to celebrate a little on injection day. You know, something fun you both like to do.

[Text on Screen] Visit HUMIRAComplete.com to request an Injection Training Kit

VICTORIA:

My dad likes to make jokes about it sometimes. He’s like “Yes, HUMIRA Thursday!”

ERIC:

Totally like OK, way to go, knuckle bump, alright, let’s get on with our evening and move on with our normal life.

VICTORIA:

Then I’ll just go do whatever like, go on my phone, or watch TV, or go to dance.

TOM:

Are you ready?

JESSICA:

Yeah.

TOM:

Alright, let’s do this.

You can find what we’re about to cover inside the package. I’ll break this down into 4 simple steps. Let’s call them the “4Ps”.

• PICK the site
• PREPARE the syringe
• PINCH the skin
• And PUSH the plunger in

[Text on Screen] 4Ps

1. PICK
2. PREPARE
3. PINCH
4. PUSH

[Text on Screen] PICK THE INJECTION SITE

So, let’s get started.

[Text on Screen] Store HUMIRA in the refrigerator until time of use.

[Text on Screen] Do not use HUMIRA if frozen, even if it has been thawed. Do not use if the medicine has passed the expiration date.

First, wash your hands and get the things you need. And settle in a place where you feel relaxed. If it’s more comfortable for your child, take the HUMIRA out of the fridge and leave it at room temp for 15 to 30 minutes before you inject. You might want to do all the prep stuff while your kid is in another room.

[Text on Screen] HUMIRA should not be frozen or exposed to direct sunlight.

CHLOE:

I’ll go downstairs and my mom will have set my shot out from the fridge.

VICTORIA:

I sit in, like, the same chair, the same way like every time. My dad does the injection, and my mom she used to, like, hold my hand. Now I just use, like, my sister’s, like, squishy little toy.

JACOB:

I would often take some sour candies. It was just a distraction.

MARK:

I tend to joke with her a lot and ease the situation. It made it a lot better for her.

VICTORIA:

Yeah.

TOM:

There’s an alcohol swab that’s included inside the package, a cotton ball (you can also use a gauze pad), a sharps container (that looks like this), and, of course, the HUMIRA prefilled syringe. Now check the syringe. Holding it with the needle pointing down, make sure the liquid is clear and colorless.

If the liquid is cloudy, has an unusual color, or has flakes or specks in it, you shouldn’t use it. Use another syringe in the fridge if you have one and call your pharmacy. If you see a few bubbles, no problem.

[Text on Screen] Do not use HUMIRA if frozen, even if thawed.

And be sure to check your medicine’s expiration date.

[Text on Screen] Do not use if the medicine has passed the expiration date.

So, have we missed anything, Jess?

JESSICA:

Nope, so far so good, Dad.

TOM:

To choose the injection site, rotate each time at least one inch from the previous injection site, and you can inject in the right or left thigh and on your stomach.

[Text on Screen] Injectable Areas

[Text on Screen] A new injection should be at least 1 inch away from the site you chose the time before

If you’re choosing the belly area, be sure it’s at least 2 inches away from the belly button. But for now, we will show you using the left thigh.

[Text on Screen] 2 inches

Clean the injection site with an alcohol swab. You shouldn’t inject through clothing. And, don’t inject into skin that doesn’t look normal.

[Text on Screen] Do not inject into skin that is sore, bruised, red, hard, scarred, raised, thick, has scaly patches, lesions, or stretch marks.

[Text on Screen] PREPARE THE SYRINGE

Gently pull the needle cover off, being careful not to let the needle touch your fingers or anything else. Now, turn the syringe so that the needle is facing up. Holding it eye-level with one hand, using your other hand to slowly push the plunger to push out any air in the needle. If you see a small drop of liquid at the tip of the needle, that’s totally normal. Now, you’re just about ready to inject.

CHLOE:

Yeah, you kinda have to pysch yourself up for it.

VICTORIA:

Breathe in, breathe out.

[Text on Screen] PINCH THE SKIN

TOM:

You may want to come up with something that helps your child think about something else, like reciting a countdown or a catchphrase.

VICTORIA:

My dad does 3, 2, 1...

CHLOE:

You’re almost there Chloe. You’re almost there and then you’re done for 2 weeks.

TOM:

Hold the body of the syringe between your thumb and index finger, like you’re holding a pencil. Don’t pull back on the plunger at all yet.

With your other hand, gently pinch the area of skin that you’ve cleaned and hold it firmly.

For this demonstration, we’re using a practice pad.

[Text on Screen] For demonstration purposes, we will be using a practice pad. Practice pad not included in package and should not be used during an actual injection.

TOM:

Now, hold the syringe at a 45° angle. And, with a quick dart-like motion, insert the needle into the skin.

[Text on Screen] 45°

Once the needle is in, let go of the pinched skin and pull gently back on the plunger.

[Text on Screen] There is no requirement to pull back on the plunger if the HUMIRA you received is in a blue box.

TOM:
There is no requirement to pull back on the plunger if the HUMIRA you received is in a blue box.

If the syringe is clear, continue injecting. But, if you see any blood in the syringe, it means you’ve entered a blood vessel, and you should stop injecting. If that’s the case, pull the needle out and throw the syringe in a sharps container right away. And start over with a new syringe if you have one. If not, call your pharmacy.

[Text on Screen] PUSH THE PLUNGER IN

Slowly push the plunger all the way in until all the liquid is injected. Your child may actually feel the medicine going in, don’t let it startle either of you.

Now that the syringe is empty, keep the syringe at the same angle and pull the needle out of the skin. OK, we’re almost done here!

Again, be careful not to touch the needle and drop it into the sharps container immediately. No need to put the cap back on the syringe.

[Text on Screen] Do not touch the needle

Gently press the injection site with a cotton ball (you can also use a gauze pad), instead of rubbing it, for 10 seconds. You might see a small amount of fluid or a drop of blood, that’s totally normal.

[Text on Screen] There may be pain, redness, rash, swelling, itching, or bruising. If it doesn’t go away within a few days or gets worse, call your child’s doctor right away.

In a nutshell, here’s what we just did:

• PICK the site
• PREPARE the syringe
• PINCH the skin
• And PUSH the plunger in

[Text on Screen]: 4Ps

1. PICK
2. PREPARE
3. PINCH
4. PUSH

TOM:

Now it’s time to clean up.

CHLOE:

So, I mean, it’s not that bad.

HEIDI:

It’s a tough injection, but it definitely is one that we’ve mastered.

TOM:

The HUMIRA Complete Sharps Disposal and Mail-back Service ensures your HUMIRA is disposed of safely and in a socially responsible way.

[Text on Screen] You can get a sharps container from HUMIRA Complete shipped to your home at no additional cost

HEIDI:

After every injection, we use the red sharps containers that HUMIRA provided us.

[Text on Screen] For more information about sharps disposal, go to the FDA website: www.fda.gov/safesharpsdisposal

VICTORIA:

Keep them up high or like in a cabinet – that’s where we keep it so then like the dogs don’t get into it.

[Text on Screen] For sharps container, call 1.800.4HUMIRA or visit HUMIRA.com

JACOB:

I set an alarm on my computer and my phone...

[Text on Screen] Schedule reminder calls, email, or texts on HUMIRA.com or call 1.800.4HUMIRA

CHLOE:

 ...and it says in all caps “SHOT” with exclamation points. It makes it really easy.

TOM:

OK, that’s it. If you have any questions, call your doctor. You can also call HUMIRA Complete at 1.800.4HUMIRA or your Nurse Ambassador. And you can always refer to this video to cover the basics. You’ve got this.

[SUPER] HUMIRA Complete logo

[Text on Screen] Call 1.800.4HUMIRA

[SUPER] HUMIRA Complete mnemonic

[SUPER] HUMIRA Complete logo

[Text on Screen] Please see Uses and Important Safety Information within the website. Please see accompanying full Prescribing Information, including Patient Instructions for Use and Medication Guide, and discuss with your child’s doctor.

[Text on Screen] [HUMIRA Complete logo]

Safety Considerations1

Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. HUMIRA may increase the chance of getting lymphoma, including a rare kind, or other cancers. HUMIRA can cause serious side effects including hepatitis B infection in carriers of the virus, allergic reactions, nervous system problems, blood problems, heart failure, certain immune reactions including a lupus-like syndrome, liver problems, and new or worsening psoriasis.

[Text on Screen] You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

[Text on Screen] Reference: 1. HUMIRA Injection [package insert]. North Chicago, IL: AbbVie Inc.