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Ulcerative colitis (UC) belongs to a larger group of illnesses called inflammatory bowel diseases (IBD) that affect the large intestine (colon and rectum) in the gastrointestinal (GI) tract. It is a chronic—or long-lasting—disease that can get worse over time if left untreated.
While the exact cause of UC is not fully understood, research shows that it could be the result of several factors, such as genetics, the environment, or an immune system malfunction.
What You Need to Know
Inflammation is your immune system’s normal reaction to protect your body from bacteria, viruses, and other potentially harmful substances. However, for people with UC, the immune system is mistakenly triggered to attack the inner lining of the large intestine. This results in excess inflammation, leading to the symptoms of UC.
Although it isn’t known for sure what triggers the excess inflammation, too much of the protein TNF alpha may be to blame. Your body’s immune system naturally produces TNF alpha, but if you have UC, your body may be producing too much of it.
Because UC is a chronic disease, symptoms can change or get worse over time. Many people go through periods when they experience few or no symptoms, known as remission, as well as periods of flare-ups when they experience frequent and/or more intense symptoms.
If you’re still experiencing symptoms, even while being treated for UC, it could be a sign that your symptoms are not under control.
Experiencing uncontrolled symptoms could mean it’s time to consider a new treatment.
While UC symptoms can vary over time and from person to person, the most common symptoms are diarrhea with blood and abdominal discomfort.
However, your symptoms may vary depending on where inflammation occurs in your GI tract and how severe it is.
Other signs and symptoms include:
*A patient does not need to have all of these factors to be considered in a specific category of disease
Ulcerative colitis symptoms are considered moderate when you experience between 4-6 stools per day which include a moderate amount of blood. Severe UC is when you experience 6-10 per day with a severe amount of blood when passing.
– Sarah, a real UC patient using HUMIRA
Changing your routine because of UC symptoms? You're not alone. Hear from others who have been there.
The goal of UC treatment is remission – few or no symptoms. This can be accomplished by reducing the chronic inflammation causing your symptoms. If your current treatment isn’t controlling your symptoms, you and your doctor may choose to explore biologics.
HUMIRA, a biologic, blocks TNF alpha, a source of inflammation that may be contributing to your symptoms. At your next appointment, ask if HUMIRA may be able to help you reach remission.
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