Rheumatoid arthritis, or RA, is a condition that will be with you for the rest of your life, interrupting the harmony and balance in your immune system.

When your immune system is overactive, it can contribute to inflammation in your body, creating symptoms like joint pain, swelling, and stiffness throughout your body in areas like your hands, knees, elbows, shoulders, and feet.

The ongoing pain and stiffness that you feel in your joints may be a sign that they’re eroding. If left untreated, the irreversible joint damage can continue to worsen over time. So, in order to help preserve joint function and stop further joint damage, it is important to talk to your rheumatologist when symptoms appear.

No one knows exactly what causes RA, but we do know that several proteins produced in your body are involved. One of these proteins is called TNF-alpha.

Normally, TNF-alpha helps regulate immune activity and the amount of inflammation in your body. But when your body produces too much TNF-alpha, it contributes to excess inflammation seen in your joints and may contribute to some of the symptoms of RA.

And while you can see the swollen joints and feel pain, even when you have no symptoms excess inflammation may still be present on a microscopic level in your body.

HUMIRA is a prescription medicine known as a TNF-alpha blocker.

When used as recommended, HUMIRA targets and blocks TNF-alpha in your body, which plays an important role in the inflammation and permanent joint damage associated with moderate to severe rheumatoid arthritis.

In clinical studies, HUMIRA helped stop further irreversible joint damage and helped reduce the signs and symptoms of moderate to severe RA.

Help stop the clock on further irreversible joint damage by talking to your rheumatologist.

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Safety Considerations

HUMIRA can lower your ability to fight infections, including tuberculosis. Serious, sometimes fatal infections and cancers, including lymphoma, have happened; as have blood, liver, and nervous system problems, serious allergic reactions, and new or worsening heart failure. Before treatment, get tested for TB. Tell your doctor if you've been to areas where certain fungal infections are common, and if you've had TB, hepatitis B, are prone to infections, or have flu-like symptoms or sores. Don't start HUMIRA if you have an infection.

Please see additional Important Safety Information on this web page.