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What is HUMIRA Citrate-free?
HUMIRA Citrate-free works the same as original HUMIRA, but with less pain immediately following injection.* The active ingredient (adalimumab) is the same as it has been for over 15 years.
If you are interested in getting started with HUMIRA Citrate-free, ask your doctor about a prescription.
*Compared to HUMIRA 40 mg/0.8 mL.
Already taking original HUMIRA and ready to transition to HUMIRA Citrate-free?
If you and your doctor decide together that HUMIRA Citrate-free is right for you, you will need to start a new prescription. You will not be automatically transitioned to HUMIRA Citrate-free.
HUMIRA Citrate-free comes in both the HUMIRA Pen and prefilled syringe, and is injected the same way as original HUMIRA.
Ask your doctor about a new prescription when you are ready for your next HUMIRA refill.
HUMIRA Citrate-free packaging
Packaging for HUMIRA Citrate-free may vary depending on the inventory of your specialty pharmacy. The easiest way to tell the difference between original HUMIRA and HUMIRA Citrate-free is to look for the 29-gauge needle call-out on the front of the package. In addition, the packaging for your starting dose of HUMIRA Citrate-free may look different from the packaging for your maintenance dose.
For more information about the HUMIRA Citrate-free packaging, call 1.800.4HUMIRA (1.800.448.6472) or to see other configurations of HUMIRA Citrate-free packaging, view the PDF
Changes you can’t see
Less pain, same HUMIRA
- HUMIRA Citrate-free is less painful immediately following injection,* but works just like original HUMIRA
- Citrate buffers associated with injection pain were removed
- The active ingredient (adalimumab) is the same as it has been for over 15 years
Needle cover
- The needle cover for the HUMIRA Citrate-free Pen and prefilled syringe is not made with natural rubber latex
*Compared to HUMIRA 40 mg/0.8 mL.
Changes you can see
Updated box
- Packaging for HUMIRA Citrate-free may vary depending on the inventory of your specialty pharmacy. Look for the 29-gauge needle call-out on the front of the box. To see other configurations of HUMIRA Citrate-free packaging, view the PDF
Thinner needle
- Look for the “29-gauge needle” call-out on your HUMIRA Citrate-free box
Less liquid
- HUMIRA Citrate-free contains less liquid with the same amount of active ingredient (adalimumab)
Redesigned Pen
- The numbers on the caps are now white, and the HUMIRA Pen has a larger viewing window
Frequently asked questions
HUMIRA Citrate-free is the same as original HUMIRA, but without citrate buffers, and includes other device enhancements. The latest HUMIRA presentation, Citrate-free, works just like original HUMIRA, but with less pain immediately following injection.* The active ingredient (adalimumab) is the same as it has been for over 15 years.
Other enhancements include a thinner needle and 50% less liquid to inject compared to original HUMIRA. The HUMIRA Pen has also been enhanced to include a larger viewing window and white numbers on the caps. And, the black needle cover is not made with natural rubber latex. HUMIRA Citrate-free comes in the HUMIRA Pen and the prefilled syringe.
If you are interested in taking HUMIRA Citrate-free, ask your doctor about a prescription before your next HUMIRA refill.
*Compared to HUMIRA 40 mg/0.8 mL.
Yes, your doctor will need to write you a prescription for HUMIRA Citrate-free whether you are just starting treatment with HUMIRA or have been taking original HUMIRA for some time. You may need to finish your current HUMIRA prescription before you can start HUMIRA Citrate-free.
If you and your doctor decide HUMIRA Citrate-free is right for you, a new prior authorization (PA) may be required depending on your insurance. A PA is a common requirement when refilling a prescription for another year or just starting a prescription for a chronic condition. However, your insurance may not cover HUMIRA Citrate-free until you are due for a refill.
If you have questions about your HUMIRA, call 1.800.4HUMIRA (1.800.448.6472).
No, you will not automatically be transitioned to HUMIRA Citrate-free. Talk to your doctor about HUMIRA Citrate-free, and decide together on the best treatment for you.
Once your doctor has written a new prescription for HUMIRA Citrate-free, you may call your specialty pharmacy to ensure they are aware of the change prior to your next refill.
To be sure you’ve received HUMIRA Citrate-free, look for a 29-gauge needle call-out on the front of your product’s packaging, along with white numbers located on the caps of the HUMIRA Pen.
Packaging for HUMIRA Citrate-free may vary, depending on the inventory of your specialty pharmacy. In addition, packaging for the starting dose of HUMIRA Citrate-free may look different than the packaging for the maintenance dose. To see other configurations of HUMIRA Citrate-free packaging, view the PDF
If you are unsure about the HUMIRA you have received, call 1.800.4HUMIRA (1.800.448.6472).
Yes, HUMIRA Citrate-free is available in both the Pen and prefilled syringe.
The HUMIRA Citrate-free Pen is similar to the Pen for original HUMIRA; however, HUMIRA Citrate-free also features enhancements such as a thinner needle, a larger viewing window, and white numbers on caps. The black needle cover of the Citrate-free Pen and prefilled syringe are not made with natural rubber latex.
Both the Pen and prefilled syringe feature a 29-gauge needle call-out on the front of the box. If you are unsure about the HUMIRA you have received, call 1.800.4HUMIRA (1.800.448.6472).
If your insurance currently covers HUMIRA, it may also cover HUMIRA Citrate-free. However, depending on your insurance plan, a new prior authorization (PA) may be required. Your insurance may also require you to finish your current supply before you can start a new prescription for HUMIRA Citrate-free.
If you are already on original HUMIRA or just getting started with HUMIRA Citrate-free and have questions about your insurance coverage, connect with an Insurance Specialist by calling 1.800.4HUMIRA (1.800.448.6472).
There are no changes to the storage and handling requirements of HUMIRA. HUMIRA Citrate-free can be stored at room temperature for up to 14 days. If not used within that time, it should be discarded.
HUMIRA Citrate-free dosing information for adult indications
It’s important to use the proper injection technique and follow the dosing schedule for your treatment with HUMIRA Citrate-free.
The recommended dose is 1 HUMIRA Pen or syringe (40 mg/0.4 mL) every other week. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
You will inject 1 HUMIRA Pen
40 mg/0.4 mL Pen
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used alone, with methotrexate, or with certain other medicines to reduce the signs and symptoms of moderate to severe rheumatoid arthritis in adults, may prevent further damage to your bones and joints, and may help your ability to perform daily activities.
The chart below explains a standard HUMIRA Citrate-free dosing schedule. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Important: You must pay attention to your starting dose—it is different than your maintenance dose and is a critical part of taking HUMIRA Citrate-free as prescribed. Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
Starting Dose Day 1
1 HUMIRA Pen (80 mg/0.8 mL)
Starting Dose Day 8
1 HUMIRA Pen (40 mg/0.4 mL)
Continuing Dose Day 22
and every other week thereafter
1 HUMIRA Pen (40 mg/0.4 mL)
On Day 22 you will begin your regularly scheduled dose of 1 HUMIRA Pen (40 mg/0.4 mL) every other week.
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used to treat adults with moderate to severe chronic plaque psoriasis who are ready for systemic therapy or phototherapy, and are under the care of a doctor who will decide if other systemic therapies are less appropriate.
The chart below explains a standard HUMIRA Citrate-free dosing schedule. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Important: You must pay attention to your starting dose—it is different than your maintenance dose and is a critical part of taking HUMIRA Citrate-free as prescribed. Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
Starting Dose Day 1*
2 HUMIRA 80 mg/0.8 mL Pens (160 mg)
Starting Dose Day 15
1 HUMIRA Pen (80 mg/0.8 mL)
Continuing Dose Day 29
and every other week thereafter
1 HUMIRA Pen (40 mg/0.4 mL)
*First dose can be administered as 2 injections in 1 day or as 1 injection per day for 2 consecutive days.
On Day 29 you will begin your regularly scheduled dose of 1 HUMIRA Pen (40 mg/0.4 mL) every other week.
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used to reduce signs and symptoms, and to achieve and maintain clinical remission in adults with moderate to severe Crohn’s disease who have not responded well to certain other medications. HUMIRA is also used to reduce signs and symptoms and achieve clinical remission in these adults who have also lost response to or are unable to tolerate infliximab.
The chart below explains a standard HUMIRA Citrate-free dosing schedule. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Important: You must pay attention to your starting dose—it is different than your maintenance dose and is a critical part of taking HUMIRA Citrate-free as prescribed. Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
Starting Dose Day 1*
2 HUMIRA 80 mg/0.8 mL Pens (160 mg)
Starting Dose Day 15
1 HUMIRA Pen (80 mg/0.8 mL)
Continuing Dose Day 29
and every other week thereafter
1 HUMIRA Pen (40 mg/0.4 mL)
*First dose can be administered as 2 injections in 1 day or as 1 injection per day for 2 consecutive days.
On Day 29 you will begin your regularly scheduled dose of 1 HUMIRA Pen (40 mg/0.4 mL) every other week.
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used in adults to help get moderate to severe ulcerative colitis under control (induce remission) and keep it under control (sustain remission) when certain other medicines have not worked well enough. It is not known if HUMIRA is effective in people who stopped responding to or could not tolerate anti-TNF medicines.
The recommended dose is 1 HUMIRA Pen or syringe (40 mg/0.4 mL) every other week. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
You will inject 1 HUMIRA Pen
40 mg/0.4 mL Pen
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used alone or with certain other medicines to reduce the signs and symptoms of psoriatic arthritis in adults, may prevent further damage to your bones and joints, and may help your ability to perform daily activities.
The chart below explains a standard HUMIRA Citrate-free dosing schedule. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Important: You must pay attention to your starting dose—it is different than your maintenance dose and is a critical part of taking HUMIRA Citrate-free as prescribed. Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
Starting Dose Day 1*
2 HUMIRA 80 mg/0.8 mL Pens (160 mg)
Starting Dose Day 15
1 HUMIRA Pen (80 mg/0.8 mL)
Continuing Dose Day 29
and every week thereafter
1 HUMIRA Pen (40 mg/0.4 mL)
*First dose can be administered as 2 injections in 1 day or as 1 injection per day for 2 consecutive days.
On Day 29 you will begin your regularly scheduled dose of 1 HUMIRA Pen (40 mg/0.4 mL) every week.
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used to reduce the signs and symptoms of moderate to severe hidradenitis suppurativa in people 12 years and older.
The recommended dose is 1 HUMIRA Pen or syringe (40 mg/0.4 mL) every other week. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
You will inject 1 HUMIRA Pen
40 mg/0.4 mL Pen
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults.
The chart below explains a standard HUMIRA Citrate-free dosing schedule. Always follow your doctor's instructions about when and how often to take HUMIRA Citrate-free.
For more information, refer to the Patient Instructions for Use, and the Medication Guide located inside your HUMIRA Citrate-free carton, and within the Full Prescribing Information.
If you have any questions about injection, you can speak to a registered nurse about your HUMIRA treatment and request in-person injection training. Just call 1.800.4HUMIRA (1.800.448.6472).
Starting HUMIRA Citrate-free
Important: You must pay attention to your starting dose—it is different than your maintenance dose and is a critical part of taking HUMIRA Citrate-free as prescribed. Make sure you have been shown how to inject HUMIRA Citrate-free before you do it yourself. Your first injection should be given under the supervision of a health care professional. Remember to keep your HUMIRA Citrate-free refrigerated in its original container until ready for use.
Starting Dose Day 1
1 HUMIRA Pen (80 mg/0.8 mL)
Starting Dose Day 8
1 HUMIRA Pen (40 mg/0.4 mL)
Continuing Dose Day 22
and every other week thereafter
1 HUMIRA Pen (40 mg/0.4 mL)
On Day 22 you will begin your regularly scheduled dose of 1 HUMIRA Pen (40 mg/0.4 mL) every other week.
Note: 40 mg/0.4 mL is also available in a prefilled syringe.
Continue taking HUMIRA Citrate-free as directed by your doctor. Remember, HUMIRA Citrate-free is a treatment, not a cure. Your doctor can tell you if and when you should stop taking HUMIRA Citrate-free.
If you experience any adverse reactions or discomfort when taking HUMIRA Citrate-free, discuss them with your doctor right away.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or does not go away.
HUMIRA Use1
HUMIRA is a prescription medicine used to treat non-infectious intermediate (middle part of the eye), posterior (back of the eye), and panuveitis (all parts of the eye) in adults and children 2 years of age and older.
HUMIRA Complete is here for you
Be sure to take advantage of all the HUMIRA Complete resources available to you, including:
- Help finding ways to save on the cost of HUMIRA, month after month, with the HUMIRA Complete Savings Card*
- Assistance with further injection training over the phone, online, and/or in person
- Access to Insurance Specialists who can help you navigate the insurance process
Before your next refill, ask your doctor about transitioning to HUMIRA Citrate-free.
*Terms and Conditions apply. This benefit covers HUMIRA® (adalimumab) alone or, for rheumatology patients, HUMIRA plus one of the following medications: methotrexate, leflunomide (Arava®), or hydroxychloroquine (Plaquenil®). Eligibility: Available to patients with commercial prescription insurance coverage for HUMIRA who meet eligibility criteria. Co-pay assistance program is not available to patients receiving prescription reimbursement under any federal, state, or government-funded insurance programs (for example, Medicare [including Part D], Medicare Advantage, Medigap, Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs) or where prohibited by law or by the patient’s health insurance provider. If at any time a patient begins receiving prescription drug coverage under any such federal, state, or government-funded healthcare program, patient will no longer be able to use the HUMIRA Complete Savings card and patient must call HUMIRA Complete at 1-800-4HUMIRA to stop participation. Patients residing in or receiving treatment in certain states may not be eligible. Patients may not seek reimbursement for value received from the HUMIRA Complete Program from any third-party payers. Offer subject to change or discontinuance without notice. Restrictions, including monthly maximums, may apply. Patients who are members of insurance plans that claim to reduce or eliminate their patients' out of pocket co-pay, co-insurance, or deductible obligations for certain prescription drugs based upon the availability of, or patient's enrollment in, manufacturer sponsored co-pay assistance for such drugs (often termed "maximizer" programs) will have an annual maximum program benefit of $6,000.00 per calendar year. This assistance offer is not health insurance. To learn about AbbVie’s privacy practices and your privacy choices, visit www.abbvie.com/privacy.html
Arava and Plaquenil are registered trademarks of their respective owners.
US-HUM-200692
