How HUMIRA (adalimumab) Works Video Transcript

[Text on screen] HUMIRA Is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults. Individual results may vary. Please see Important Safety Information in video and on this web page. Please see Full Prescribing Information including Medication Guide, on this website.

Ankylosing spondylitis, or AS, is a condition that will be with you for the rest of your life, interrupting the harmony and balance in your immune system.

When your immune system is overactive, it can contribute to inflammation in your body, creating symptoms that typically start with pain and stiffness in your neck and lower back. Over time, it could affect new areas like your hips, shoulders, and feet.

The ongoing pain and stiffness that you feel in your joints may be a sign of increased inflammation.

If left untreated, AS pain can continue to worsen over time.

So, in order to reduce the signs and symptoms of AS back pain, and improve daily physical function, it is important to talk to your rheumatologist when symptoms appear.

No one knows exactly what causes AS, but we do know that several proteins produced in your body are involved.

One of these proteins is called TNF-alpha. Normally, TNF-alpha helps regulate immune activity and the amount of inflammation in your body.

But when your body produces too much TNF-alpha, it contributes to excess inflammation seen in your joints and may contribute to some of the symptoms of Ankylosing Spondylitis. And while you can feel back pain and stiffness even when you have no symptoms, excess inflammation may still be present on a microscopic level in your body.

HUMIRA is a prescription medicine known as a TNF-alpha blocker.

When used as recommended, HUMIRA targets and blocks TNF-alpha in your body, which plays an important role in the inflammation, back pain, and stiffness associated with ankylosing spondylitis.

In clinical studies, HUMIRA has been proven to reduce the back pain and stiffness of AS.

Help stop chronic back pain and stiffness by talking to your rheumatologist.

[Text on screen] Safety Considerations: HUMIRA can lower your ability to fight infections, including tuberculosis. Serious, sometimes fatal infections and cancers, including lymphoma, have happened; as have blood, liver, and nervous system problems, serious allergic reactions, and new or worsening heart failure. Before treatment, get tested for TB. Tell your doctor if you’ve been to areas where certain fungal infections are common, and if you’ve had TB, hepatitis B, are prone to infections, or have flu-like symptoms or sores. Don’t start HUMIRA if you have an infection.