Watch this short video to get a better understanding of how HUMIRA targets and blocks tumor necrosis factor (TNF).More Information About What
One factor involved in Crohn’s disease is TNF. TNF plays a role in inflammation as part of the body’s normal defense mechanism, and is found throughout the body. However, overproduction of TNF is associated with inflammation that can be harmful. In Crohn's disease, inflammation primarily affects the digestive tract and can also affect other parts of the body. This can trigger symptoms of Crohn's disease.
HUMIRA belongs to a class of biologic medicines known as TNF blockers. It specifically binds to TNF and blocks it from acting within the body. This helps reduce the inflammation that can lead to the symptoms of Crohn’s disease.
It’s important that both you and your child speak with your child’s gastroenterologist about the benefits and risks of taking a biologic medication. It may also be important that your child understands what is happening inside his or her body and the decisions that have been made about his or her treatment plan. Prescription medications, including HUMIRA, have possible risks involved with treatment, so it’s important to discuss these risks with a doctor. HUMIRA is not right for everyone.
Because HUMIRA blocks the action of TNF, it can lower the ability of your child's immune system to fight infections. Your child should not start taking HUMIRA if he or she has any kind of infection unless your child's doctor says it’s okay. People treated with HUMIRA have an increased chance of developing serious infections that may lead to hospitalization or death, and may increase the chance of getting lymphoma (including a rare kind), skin or other cancers. You should discuss the potential benefits and risks of HUMIRA with your child's doctor.
Because HUMIRA is taken by injection, you and your child may understandably have questions about how to administer your child’s medicine. You may also have questions about pediatric Crohn’s disease or HUMIRA in general. Our HUMIRA Ambassadors are provided as a resource for you and your child at no additional cost. Because they have received in-depth training on pediatric Crohn's disease and HUMIRA, they have the knowledge of what you and your child may be going through.
Your HUMIRA Ambassador can teach you and your child about pediatric Crohn’s disease and provide support based on your individual needs. HUMIRA Ambassadors are available through HUMIRA Complete, an optional product support program offered to you by AbbVie that includes services such as injection training, financial assistance information, and more. Your HUMIRA Ambassador can provide you with one-to-one customized education and support as well as assist you with the other services provided through HUMIRA Complete.
Enroll in HUMIRA Complete here by calling 1.800.4HUMIRA (select the option to speak with a nurse).
It’s normal to have questions about pediatric Crohn’s disease. Check out our FAQ section for some answers that you may be looking for.
You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a TNF blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay.
Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.
Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, your chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life-threatening if treated; tell your doctor if you have a bump or open sore that doesn’t heal.
Tell your doctor about all of your health conditions, including if you:
Also tell your doctor about all the medicines you take. You should not take HUMIRA with ORENCIA® (abatacept), KINERET® (anakinra), REMICADE® (infliximab), ENBREL® (etanercept), CIMZIA® (certolizumab pegol), or SIMPONI® (golimumab). Tell your doctor if you have ever used RITUXAN® (rituximab), IMURAN® (azathioprine), or PURINETHOL® (mercaptopurine, 6-MP).
HUMIRA can cause serious side effects, including:
Call your doctor or get medical care right away if you develop any of the above symptoms.
Common side effects of HUMIRA include injection site reactions (redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or that does not go away.
HUMIRA is given by injection under the skin.
HUMIRA is a prescription medicine used:
HUMIRA is a prescription medicine used to reduce signs and symptoms, and to achieve and maintain clinical remission in children 6 years of age and older with moderate to severe Crohn’s disease when certain other treatments have not worked well enough.
Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. HUMIRA may increase the chance of getting lymphoma, including a rare kind, or other cancers. HUMIRA can cause serious side effects including hepatitis B infection in carriers of the virus, allergic reactions, nervous system problems, blood problems, heart failure, certain immune reactions including a lupus-like syndrome, liver problems, and new or worsening psoriasis.