Watch this short video to get a better understanding of how HUMIRA targets and helps to block TNF, a specific source of inflammation that contributes to polyarticular juvenile idiopathic arthritis (JIA) symptoms.View Transcript
One factor involved in juvenile idiopathic arthritis is the production of too much of a protein called tumor necrosis factor (TNF). Some children with JIA have too much TNF in the affected joints. This extra TNF can cause inflammation, which can contribute to the joint pain, swelling, and stiffness of JIA.
The immune system can overproduce a protein called TNF, one source of inflammation. HUMIRA targets and helps block TNF-alpha, one of the sources of joint pain, stiffness, and swelling.
Talk to your child’s pediatric rheumatologist about the benefits and risks of taking a biologic medication. Prescription medications, including HUMIRA, have possible risks involved with treatment, so it's important to discuss them with your child's doctor. If your child is still experiencing symptoms of moderate to severe polyarticular JIA despite current treatment, ask your child's doctor about HUMIRA.
HUMIRA is not right for everyone.
Because HUMIRA blocks the action of TNF, it can lower the ability of your child’s immune system to fight infections. Your child should not start taking HUMIRA if he or she has any kind of infection unless the child’s doctor says it’s okay. People treated with HUMIRA have an increased chance of developing serious infections that may lead to hospitalization or death, and may increase the chance of getting lymphoma (including a rare kind), skin or other cancers. You should discuss the potential benefits and risks of HUMIRA with your child’s doctor.
You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a TNF blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay.
Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.
Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, your chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life-threatening if treated; tell your doctor if you have a bump or open sore that doesn’t heal.
Tell your doctor about all of your health conditions, including if you:
Also tell your doctor about all the medicines you take. You should not take HUMIRA with ORENCIA® (abatacept), KINERET® (anakinra), REMICADE® (infliximab), ENBREL® (etanercept), CIMZIA® (certolizumab pegol), or SIMPONI® (golimumab). Tell your doctor if you have ever used RITUXAN® (rituximab), IMURAN® (azathioprine), or PURINETHOL® (mercaptopurine, 6-MP).
HUMIRA can cause serious side effects, including:
Call your doctor or get medical care right away if you develop any of the above symptoms.
Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or that does not go away.
HUMIRA is given by injection under the skin.
HUMIRA is a prescription medicine used:
How HUMIRA Works
HUMIRA is a prescription medicine used alone, with methotrexate, or with certain other medicines to reduce the signs and symptoms of moderate to severe polyarticular juvenile idiopathic arthritis in children 2 years of age and older.
Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. HUMIRA may increase the chance of getting lymphoma, including a rare kind, or other cancers. HUMIRA can cause serious side effects including hepatitis B infection in carriers of the virus, allergic reactions, nervous system problems, blood problems, heart failure, certain immune reactions including a lupus-like syndrome, liver problems, and new or worsening psoriasis.