"HUMIRA CITRATE-FREE ADULT SELF-INJECTION SYRINGE" TRANSCRIPT

[Text on Screen and Spoken] This demonstration video offers you help and guidance for injecting with the HUMIRA® prefilled syringe. Watch it and read the entire Patient Instructions for Use found in your HUMIRA package. Don’t try to inject HUMIRA yourself until your doctor has decided you can, and you’ve been shown the right way to give injections.

Throughout this video, you will hear from actual patients. Individual experiences may vary.

[Text on Screen] Please see Uses and Important Safety Information within the website. Please see accompanying full Prescribing Information, including Patient Instructions for Use and Medication Guide, and discuss with your doctor.

[SUPER] HUMIRA Complete mnemonic

[Text on Screen] INJECTING HUMIRA WITH RESOURCES DESIGNED AROUND YOU

JANET:

Hi, how are you? I’m Janet. And I know that there are a million things you’d rather be doing right now than learning about injecting your medication...I get it. Before we start, I want you to know that there are a lot more ways HUMIRA Complete can help you out than with this video. Because, well, let’s be real...there’s more to making HUMIRA a routine part of your life than just learning how to inject.

If you are concerned about being able to afford your medication, or have questions about insurance, or are wondering how you can do this on your own, HUMIRA Complete can help get you the answers you need when you need them. You even have a dedicated Nurse Ambassador available to you. Whether you are just starting or have been taking it awhile, HUMIRA Complete is there for you.

[Text on Screen] Call 1.800.4HUMIRA
[Text on Screen] Request a HUMIRA Complete Nurse Ambassador* at 1.800.4HUMIRA

*Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.

Everyone has a different perspective about injecting, and throughout this video, you will hear from some actual patients.

[Text on Screen] Visit HUMIRAComplete.com to request an Injection Training Kit

LINDSEY:

I was very hesitant; my first thought was “you’ve been terrified of needles since you were a child.”

STEVEN:

Obviously it involves a little bit more than just taking a pill and what it would feel like.

DANAY:

It’s okay to be nervous. It’s okay to feel nervous. But, if this is something that’s gonna help me continue to move forward, why not give it a try?

LAURA:

Luckily, my Nurse Ambassador—she was awesome. So she came and she really was patient, took her time with me.

MICHAEL:

They have been very good about calling and keeping up with what’s going on.

JANET:

So, let’s clear some things up. Ready? Let’s do this.

First, wash your hands and get the things you need. And settle in a place where you feel relaxed.

[Text on Screen] Store HUMIRA in the refrigerator until time of use.

[Text on Screen] Do not use HUMIRA if frozen, even if it has been thawed. Do not use if the medicine has passed the expiration date.

If it’s more comfortable for you, take your HUMIRA out of the fridge and leave it at room temp 15 to 30 minutes before you inject.

[Text on Screen] HUMIRA should not be frozen or exposed to direct sunlight.

LAURA:

Like I think having the routine in the beginning until I was comfortable made a lot of sense for me.

LINDSEY:

I lay everything out, I plan which side I’m going to inject, and I think the process actually calms me down.

DANAY:

I knew that one day I’m gonna have to do it on my own, so I just sucked it up and I did it.

JANET:

There’s an alcohol swab that’s included inside the package, a cotton ball (you can also use a gauze pad), a sharps container (that looks like this), and, of course, the HUMIRA prefilled syringe. Now check the syringe. Holding the syringe with the needle pointing down, make sure the liquid is clear and colorless. If the liquid is cloudy, has an unusual color...or has flakes or specks in it, you shouldn’t use it. Use another syringe in the fridge if you have one and call your pharmacy. If you see a few bubbles, no problem. And be sure to check the medicine’s expiration date. So far, so good?

You can find what we’re about to cover inside the package. I’ll break this down into 4 simple steps...Let’s call them the “4 Ps”.

• PICK the injection site
• PREPARE the syringe
• PINCH the skin
• And PUSH the plunger in

[Text on Screen] 4Ps

1. PICK
2. PREPARE
3. PINCH
4. PUSH

[Text on Screen] PICK THE INJECTION SITE

To pick your site, rotate each time at least one inch from the previous injection site; you can inject in the right or left thigh or on your stomach.

[Text on Screen] Injectable Areas

[Text on Screen] A new injection should be at least 1 inch away from the site you chose the time before

[Text on Screen] 2 inches

If you choose the lower stomach area, make sure it’s at least 2 inches away from your belly button.

Clean the site with an alcohol swab. You shouldn’t inject through clothing. And don’t inject into any skin that doesn’t look normal.

[Text on Screen] Do not inject into skin that is sore, bruised, red, hard, scarred, raised, thick, has scaly patches, lesions, or stretch marks.

[Text on Screen] PREPARE THE SYRINGE

JANET:

Gently pull the gray cover off, being careful not to let the needle touch your fingers or anything else. Now, turn the syringe so that the needle is facing up, holding it eye level with one hand, using your other hand to slowly push the plunger to push out any air in the needle. If you see a small drop of liquid at the tip of the needle, that’s totally normal. Okay, you’re just about ready to inject. If you’re still a little nervous...I totally get it.

DANAY:

Try to think about something else, like TV or something to distract you.

STEVEN:

Just listen to your favorite music.

LAURA:

Honestly, and remembering to breathe. That’s huge!

DANAY:

Take a deep breath in...

STEVEN:

And then exhale.

DANAY:

And I just did it, one two three and it was over!

[Text on Screen]

PINCH THE SKIN

JANET:

For this demonstration, I’ll be using a practice pad. Hold the body of the syringe between your thumb and index finger, like you’re holding a pencil. With your free hand, gently pinch the area of skin that you’ve cleaned and hold it firmly.

[Text on Screen] For demonstration purposes, we will be using a practice pad. Practice pad not included in package and should not be used during an actual injection.

[Text on Screen] PUSH THE PLUNGER IN

JANET:

Now...

Hold the syringe at a 45° angle, and with a quick, dart-like motion, insert the needle into the pinched skin. Once the needle is in, let go of the pinched skin and pull back gently on the plunger. There is no requirement to pull back on the plunger if the HUMIRA you received is in a blue box.

[Text on Screen] 45°

[Text on Screen] There is no requirement to pull back on the plunger if the HUMIRA you received is in a blue box.

If the syringe is clear, continue injecting. But if you were to see any blood in the syringe it would mean you’ve entered a blood vessel, and you should stop injecting. If this is the case, pull the needle out and throw the syringe in the sharps container right away. And start over with a new syringe if you have one. If not, call your pharmacy. Slowly push the plunger all the way in until all the liquid is injected. You may actually feel the medicine going in. Don’t let it startle you.

Now that the syringe is empty, keep the syringe at the same angle, and pull the needle out of the skin.

Be careful not to touch the needle. No need to put the cap back on the syringe.

[Text on Screen] There may be pain, redness, rash, swelling, itching, or bruising. If it doesn’t go away within a few days or gets worse, call your doctor right away.

And immediately drop it into the sharps container.

[Text on Screen] Do not touch the needle

Instead of rubbing the site, gently press a cotton ball (or gauze) for 10 seconds. There may be a small amount of fluid or a drop of blood...which is totally normal.

STEVEN:

It definitely hurt less than I had imagined it.

LAURA:

All those nerves I had in the beginning, now it’s kind of almost nothing.

JANET:

 In a nutshell, here’s what we just did:

• PICK the site
• PREPARE the syringe
• PINCH the skin
• And PUSH the plunger in

[Text on Screen]: 4Ps

1. PICK
2. PREPARE
3. PINCH
4. PUSH

LINDSEY:

I made it through it.

MICHAEL:

You just have to get over that fear.

DANAY:

I have confidence, I know what I’m doing, I’m a pro, that’s what it is—I’m a pro!

JANET:

The HUMIRA Complete Sharps Disposal and Mail-back Service ensures your HUMIRA is disposed of safely and in a socially responsible way.

[Text on Screen] You can get a sharps container from HUMIRA Complete shipped to your home at no additional cost

[Text on Screen] For more information about sharps disposal, go to the FDA website: www.fda.gov/safesharpsdisposal

LINDSEY:

I put it in a sharps container.

LAURA:

I actually keep it on a shelf in my bedroom so it is out of reach. When it starts getting full, I call and they send me a new one and the box to send it back.

[Text on Screen] For sharps container, call 1.800.4HUMIRA or visit HUMIRA.com

DANAY:

It doesn’t cost me anything to send back the sharps container, which is good.

STEVEN:

The HUMIRA Complete app, it keeps on a two-week schedule.

[Text on Screen] Get it in the App Store or Google Play

Search HUMIRA Complete

LAURA:

It gave me every tool that I need to understand what I’m doing and how to do it.

MICHAEL:

They will text that I’ve got an injection coming up.

[Text on Screen] Schedule reminder calls, email, or texts on HUMIRA.com or call 1.800.4HUMIRA

DANAY:

It feels great to be able to be in control of my own medicine.

LINDSEY:

I completely own this disease, as well as my own health.

JANET:

OK, that’s it. If you have any questions, call your doctor. You can also call HUMIRA Complete at 1.800.4HUMIRA or your Nurse Ambassador. And you can always refer to this video to cover the basics. You’ve got this.

[SUPER] HUMIRA Complete logo

[Text on Screen] Call 1.800.4HUMIRA

[SUPER] HUMIRA Complete mnemonic

[SUPER] HUMIRA Complete logo

[Text on Screen] Please see Uses and Important Safety Information within the website. Please see accompanying full Prescribing Information, including Patient Instructions for Use and Medication Guide, and discuss with your doctor.

[Text on Screen] Safety Considerations1

Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. HUMIRA may increase the chance of getting lymphoma, including a rare kind, or other cancers. HUMIRA can cause serious side effects including hepatitis B infection in carriers of the virus, allergic reactions, nervous system problems, blood problems, heart failure, certain immune reactions including a lupus-like syndrome, liver problems, and new or worsening psoriasis.

[Text on Screen] You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

[Text on Screen] Reference: 1. HUMIRA Injection [package insert]. North Chicago, IL: AbbVie Inc.