Watch this short video to get a better understanding of how HUMIRA targets and helps block tumor necrosis factor (TNF) to help reduce the signs and symptoms of ankylosing spondylitis (AS).View Transcript
In one clinical study, more than twice as many patients experienced reduced symptoms of ankylosing spondylitis with HUMIRA versus placebo at 12 weeks.
Reduction in AS signs and symptoms
58%of people who took HUMIRA 21%of people who took placebo
When compared with a placebo in a clinical study, more people taking HUMIRA showed a 20% reduction in the signs and symptoms of AS at 12 weeks.
Some patients with AS see results in as soon as 2 weeks, however it may take up to 3 months or longer to notice improvement.
Individual results may vary.
Patients on HUMIRA continued to experience a reduction in signs and symptoms for up to 52 weeks.
Ankylosing spondylitis has been linked to an overproduction of a protein called TNF. In people with AS, this TNF contributes to inflammation, which can lead to back pain and stiffness.
HUMIRA, as a TNF-alpha blocker, binds to TNF-alpha and helps block one source of inflammation that contributes to AS symptoms. Because TNF-alpha blockers, including HUMIRA, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects.
Talk to your doctor about the benefits and risks of taking a biologic medication. Prescription medications, including HUMIRA, have possible risks involved with treatment, so it's important to discuss them with your doctor. If you're still experiencing symptoms of AS despite your current treatment, ask your doctor about HUMIRA.
HUMIRA is not right for everyone.See More About What to Expect from HUMIRA
You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a TNF blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay.
Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.
Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, your chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life-threatening if treated; tell your doctor if you have a bump or open sore that doesn’t heal.
Tell your doctor about all of your health conditions, including if you:
Also tell your doctor about all the medicines you take. You should not take HUMIRA with ORENCIA® (abatacept), KINERET® (anakinra), REMICADE® (infliximab), ENBREL® (etanercept), CIMZIA® (certolizumab pegol), or SIMPONI® (golimumab). Tell your doctor if you have ever used RITUXAN® (rituximab), IMURAN® (azathioprine), or PURINETHOL® (mercaptopurine, 6-MP).
HUMIRA can cause serious side effects, including:
Call your doctor or get medical care right away if you develop any of the above symptoms.
Common side effects of HUMIRA include injection site reactions (redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or that does not go away.
HUMIRA is given by injection under the skin.
HUMIRA is a prescription medicine used:
HUMIRA is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults.
Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. HUMIRA may increase the chance of getting lymphoma, including a rare kind, or other cancers. HUMIRA can cause serious side effects including hepatitis B infection in carriers of the virus, allergic reactions, nervous system problems, blood problems, heart failure, certain immune reactions including a lupus-like syndrome, liver problems, and new or worsening psoriasis.