What Causes Ulcerative Colitis?
The exact cause of ulcerative colitis (UC) and what triggers it is not fully understood. However, research indicates that it is a result of a combination of factors involving genetics, the environment, and the immune system.
Ulcerative Colitis and the Immune System
In people with ulcerative colitis, researchers believe substances in the intestine are mistaken for foreign invading substances (antigens). These antigens may be the direct cause of the inflammation, or they may stimulate the body's defenses to produce an inflammatory reaction.
Ulcerative Colitis and Inflammation
One factor involved in ulcerative colitis is producing too much of a protein called TNF (tumor necrosis factor).
This overproduction of TNF in the colon can cause it to become inflamed, which can result in pain, diarrhea,
and other symptoms of ulcerative colitis.
HUMIRA Targets TNF
HUMIRA belongs to a class of biologic medicines known as TNF blockers. HUMIRA specifically binds to TNF to block its action on the large intestine. This helps reduce the inflammation associated with moderate to severe ulcerative colitis.
While HUMIRA can block TNF, it can also affect how your immune system normally works, and may cause serious side effects.
HUMIRA is not right for everyone. Only your doctor can decide if it is right for you.