HUMIRA and Methotrexate
Many doctors prescribe HUMIRA to patients with moderate to severe RA who are already
taking methotrexate. In clinical trials, patients taking HUMIRA and methotrexate
saw better results than those taking methotrexate alone. In a study of patients
with early, moderate to severe RA (diagnosed for less than 3 years, not previously
treated with methotrexate), combining HUMIRA and methotrexate showed:
- 6 out of 10 patients experienced a 50% improvement of signs and symptoms at one year, compared to 46% of patients taking methotrexate alone
- Almost 2 out of 3 people treated with HUMIRA and methotrexate had no further joint damage after 1 year (compared to 37% taking methotrexate alone)
- The combination of HUMIRA and methotrexate was an average of 4 times more effective at one year in slowing the progression of joint damage than methotrexate alone
Medications used to treat RA can have serious side effects. Make sure to tell your
doctor about all the medications you're currently taking.
A prescription medication taken by injection, HUMIRA can be injected by you or a
caregiver in the convenience of your own home. It usually needs to be used once
every 2 weeks, however, some RA patients not taking methotrexate may benefit from
Do not try to inject HUMIRA yourself until you have been shown the right way to
give the injections. If your doctor decides that you may be able to give your injections
at home, you should receive training on the right way to prepare and inject HUMIRA.
Your first injection should be given under the supervision of a qualified healthcare
One of the most common side effects with HUMIRA is injection site reactions such
as redness, rash, swelling, itching or bruising. These symptoms usually will go
away within a few days.
HUMIRA is a prescription medicine used alone, with methotrexate, or with certain other medicines to reduce the
signs and symptoms of moderate to severe rheumatoid arthritis in adults, may prevent further damage to your bones and joints,
and may help your ability to perform daily activities.