How HUMIRA Works
Voice Over (V.O.):
The video you’re about to watch takes you underneath the surface of the skin to show how HUMIRA (adalimumab) works inside the body. Please watch the Safety Considerations Video and read the Important Safety Information on this Web page.
Hi, I’m Dr. Cather, and I’m a dermatologist. As a physician who specializes in treating conditions of the skin, I’ve been treating plaque psoriasis patients for 13 years. If you’ve been living with plaque psoriasis, then you’ve seen the effects it can have on the surface of your skin. But what’s going on underneath the surface, inside your body?
While the exact cause is still unknown, plaque psoriasis is an immune disease, and also an inflammatory disease. This means your immune system is working too hard, causing it to send out signals that trigger your skin cells to grow at a faster rate.
The inflammation underneath your skin can be seen on the surface in the form of raised red, itchy skin patches called plaques.
One method of treating moderate to severe chronic plaque psoriasis is to block the process of inflammation underneath your skin. That is where HUMIRA may play a role. Please refer to the full Prescribing Information on this Web site, including Medication Guide, and discuss it with your doctor.
HUMIRA is a prescription medicine used to treat adults with moderate to severe chronic plaque psoriasis who are ready for systemic therapy or phototherapy, and are under the care of a doctor who will decide if other systemic therapies are less appropriate.
HUMIRA is not for everyone and can cause serious side effects, including lowering the ability of your immune system to fight infections.
HUMIRA is a biologic, and it is given by injection in order to work inside your body.
To explain, let’s take another look underneath the surface of your skin. One of the causes of plaque psoriasis is tumor necrosis factor alpha, or TNF-alpha.
When your immune system works at a normal rate, your skin cells move easily and replace themselves every 28 to 30 days. But with plaque psoriasis, and too much TNF-alpha, the growth cycle of skin cells is sped up, causing the cells to pile up and form plaques.
That’s when HUMIRA steps in. HUMIRA is a TNF-alpha blocker. HUMIRA binds on the TNF-alpha, blocking inflammation underneath your skin.
HUMIRA can reduce the excess buildup of skin cells that result in plaques.
In clinical trials, most adults who used HUMIRA for moderate to severe chronic plaque psoriasis saw 75% skin clearance and the majority of people were clear or almost clear in just 4 months.
HUMIRA is given by an injection under the skin, using the HUMIRA pen. HUMIRA is injected so that it can help fight the skin inflammation throughout your body. Your dermatologist can prescribe HUMIRA, and will administer the first injection for you.
Further injections you’ll do yourself at home, but not before your dermatologist makes sure you’re comfortable. Common reactions at the injection site include: redness, rash, swelling, itching, or bruising. These usually go away within a few days.
HUMIRA is not for everyone. It’s important to partner with your dermatologist to find a medication that’s right for you.
Ask your dermatologist about HUMIRA today.