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About HUMIRA

HUMIRA Is a Medicine Called a TNF Blocker

Rheumatoid Arthritis (RA) is an autoimmune disease that has been linked to a protein produced in the body called TNF (tumor necrosis factor) that can cause inflammation. People with RA have too much TNF in the affected areas of the body.

HUMIRA works by binding TNF and helps block the process that can lead to the pain, inflammation, and progression of joint damage that RA can cause. Because TNF blockers, including HUMIRA, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects.

Fight Back. Talk to Your Doctor About HUMIRA.

Just coming to this site is a step forward. But don't stop here. Do some research. Talk to your doctor and learn more about your treatment options. Find out if HUMIRA may be right for you.

HUMIRA just might make a real difference in your fight against RA.

HUMIRA is used to reduce the signs and symptoms of moderate to severe rheumatoid arthritis in adults. And it may help prevent further damage to your bones and joints, and improve your ability to perform daily activities. HUMIRA is a prescription medication taken by injection. It may be used alone or with methotrexate or with certain other medicines.

Safety Considerations

Serious infections have happened in patients taking HUMIRA. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. HUMIRA may increase the chance of getting lymphoma or other cancers. HUMIRA can cause serious side effects including allergic reactions, hepatitis B virus reactivation, nervous system problems, blood problems, heart failure, certain immune reactions (including a lupus-like syndrome), and new or worsening psoriasis. Please click here for additional Important Safety Information you should know about HUMIRA and discuss it with your doctor.

HUMIRA and Methotrexate: A Proven Combination

Many doctors prescribe HUMIRA to patients with moderate to severe RA who are already taking methotrexate. In clinical trials, patients taking HUMIRA and methotrexate saw better results than those taking methotrexate alone. In a study of patients with early, moderate to severe RA (diagnosed for less than 3 years, not previously treated with methotrexate), combining HUMIRA and methotrexate showed:

  • Almost 2 out of 3 people had no further joint damage at 1 year (compared to 37% taking methotrexate alone).
  • It was an average of 5 times more effective at slowing the progression of joint damage than methotrexate at 2 years.

Medications used to treat RA can have serious side effects. Make sure to tell your doctor about all the medications you're taking.

Learn More

To learn more about HUMIRA, visit the following pages:

Important Safety Information About HUMIRA® (adalimumab)

What is the most important information I should know about HUMIRA?

You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a TNF-blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection.

  • Serious infections have happened in patients taking HUMIRA. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before starting HUMIRA, and monitor you closely for signs and symptoms of TB during treatment with HUMIRA. If your doctor feels you are at risk, you may be treated with medicine for TB.
  • Certain types of Cancer. There have been cases of unusual cancers in children and teenagers using TNF-blocker medicines. For children and adults taking TNF-blocker medicines, including HUMIRA, the chance of getting lymphoma or other cancers may increase. Some patients have developed non-melanoma skin cancer; tell your doctor if you have a bump or open sore that doesn’t heal.

What should I tell my doctor BEFORE starting HUMIRA?

Tell your doctor about all of your health conditions, including if you:

  • Have an infection, are being treated for infection, or have signs of an infection
  • Get a lot of infections or have infections that keep coming back
  • Have any open cuts or sores on your body
  • Have diabetes
  • Have TB or have been in close contact with someone with TB, or were born in, lived in, or traveled where there is more risk for getting TB
  • Live or have lived in an area (such as the Ohio and Mississippi River valleys) where there is an increased risk for getting certain kinds of fungal infections, such as histoplasmosis, coccidioidomycosis, or blastomycosis
  • Have or have had hepatitis B
  • Are scheduled for major surgery
  • Have numbness or tingling or have a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Have heart failure or other heart conditions
  • Have recently received or are scheduled to receive a vaccine. Patients receiving HUMIRA should not receive live vaccines
  • Are allergic to rubber or latex, or any ingredients of HUMIRA
  • Are pregnant, planning to become pregnant, or breastfeeding

Also tell your doctor about all the medicines you take, especially Kineret (anakinra). Some medicines that suppress the immune system may increase your risk of serious infections.

What should I watch for AFTER starting HUMIRA?

HUMIRA can cause serious side effects, including:

  • Serious infections. These include TB and infections caused by viruses, fungi, or bacteria. Symptoms related to TB include cough, low-grade fever, weight loss, or loss of body fat and muscle.
  • Allergic reactions. Signs of a serious allergic reaction include skin rash, a swollen face, or trouble breathing.
  • Hepatitis B virus reactivation in patients that carry the virus in their blood. Symptoms include feeling unwell, poor appetite, tiredness, fever, rash, or joint pain.
  • Nervous system problems. Signs and symptoms include numbness or tingling, problems with your vision, weakness in your arms or legs, and dizziness.
  • Blood problems. Symptoms include a fever that does not go away, bruising or bleeding very easily, or looking very pale.
  • New heart failure or worsening of heart failure you already have. Symptoms include shortness of breath or swelling of your ankles or feet, or sudden weight gain.
  • Immune reactions including a lupus-like syndrome. Symptoms include chest discomfort or pain that does not go away, shortness of breath, joint pain, or rash on your cheeks or arms that gets worse in the sun.
  • Psoriasis (new or worsening). Symptoms include red scaly patches or raised bumps that are filled with pus.

Call your doctor or get medical care right away if you develop any of the above symptoms.

Common side effects of HUMIRA include injection site reactions (redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or that does not go away.

Remember, call your doctor right away if you have an infection or any signs of an infection, including:

  • A fever
  • Feeling very tired
  • A cough
  • Flu-like symptoms
  • Warm, red, or painful skin
  • Open cuts or sores on your body

This is the most important information to know about HUMIRA. For more information, talk to your health care provider.

Information You Should Know About HUMIRA® (adalimumab)

HUMIRA is a medicine called a tumor necrosis factor (TNF) blocker. HUMIRA is taken by injection and is available by prescription only.

HUMIRA is used to:

  • Reduce the signs and symptoms of:
    • moderate to severe rheumatoid arthritis (RA) in adults. HUMIRA can be used alone or with methotrexate or with certain other medicines. HUMIRA may prevent further damage to your bones and joints and may help your ability to perform daily activities.
    • moderate to severe polyarticular juvenile idiopathic arthritis (JIA) in children 4 years of age and older. HUMIRA can be used alone or with methotrexate or with certain other medicines.
    • psoriatic arthritis (PsA) in adults. HUMIRA can be used alone or with certain other medicines. HUMIRA may prevent further damage to your bones and joints and may help your ability to perform daily activities.
    • ankylosing spondylitis (AS) in adults.
    • moderate to severe Crohn's disease (CD) in adults who have not responded well to conventional treatments. HUMIRA is also for these adults who have lost response to or are unable to tolerate infliximab.
  • Treat moderate to severe chronic (lasting a long time) plaque psoriasis (Ps) in adults who are under the ongoing care of a physician, have the condition in many areas of their body, and who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills). When considering HUMIRA, your physician will determine if other systemic therapies are medically less appropriate.

Please see the full prescribing information, including the Medication Guide, for HUMIRA.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact: www.pparx.org or call the toll-free phone number (1-888-4PPA-NOW) for assistance.

Legal Notices/Privacy Policy. Copyright 2009, Abbott Laboratories, Abbott Park, Illinois, U.S.A. If you have any questions about Abbott's HUMIRA.com Web site that have not been answered click here. This website and the information contained herein is intended for use by US residents only, is provided for informational purposes only and is not intended to replace a discussion with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider and consider the unique characteristics of each patient.

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